Abstract

Objective

In our study we aimed to evaluate the relationship between whole blood viscosity (WBV) and the complexity and severity of coronary artery disease (CAD), in patients diagnosed with non-ST segment elevation acute coronary syndrome (NSTE-ACS).

Material and Methods

Two hundred and five patients who were admitted with the diagnosis of NSTE-ACS between 01.01.2018-30.06.2019 and who underwent coronary angiography were analyzed retrospectively. WBV was calculated for both low shear rate (LSR at 0.5/s) and high shear rate (HSR at 208/s) through formulas using hematocrit (%) and total plasma protein concentration (g/L). The study population was divided into two groups according to SYNTAX as low (<23), moderate and high risk group (≥23). Moreover the study population divided into two groups according to Gensini score median values as <30 and ≥30.

Results

There was no statistically siginficant difference betweeen the two SYNTAX groups for both WBV_HSR (16.4±1.02 vs. 16.1±1.1, p=0.139) and WBV_LSR (44.2±21.09 vs. 48.35±22.62, p=0.155). Also there was no statistically significant difference between the two Gensini groups for both WBV_HSR (16.2±1.07 vs. 16.5±1.04, p=0.183) and WBV_LSR (41.2±21.9 vs. 45.1±21.4, p=0.210). As a result of multivariate regression analysis, diabetes mellitus (p=0.037) and left ventricular ejection fraction (LVEF) (p=0.002) founded as independent predictors for high SYNTAX score, while mean platelet volume mean platelet volume (p=0.039) and LVEF (p=0.033) founded as independent predictors for high Gensini score.

Conclusion

In patients admitted with the diagnosis of NSTE-ACS we found that the severity and complexity of CAD can not be predicted by WBV.