Abstract
Objective
In our study, we examined the relationship between cardiac arrhythmia predictive parameters and migraine. The clinical symptoms of migraine are generally attributed to involvement of the autonomic nervous system, particularly the disruption of circulatory control and autonomic balance. Migraine is a common neurovascular disease with a complex relationship with cerebrovascular and cardiovascular disorders. It can cause cardiac arrhythmias by affecting the autonomic nervous system of the heart with its neurological and vascular components
Material and Methods
Patients who had been followed up with migraine for at least three years were included in the study. Patients with a history of cardiac arrhythmia or those using any antiarrhythmics were excluded from the study. All patients were in sinus rhythm and electrocardiogram records were examined and PWST, Tp-e, Tp-e/QTc and electrophysiological balance index-c (ICEB-c) were compared with the control group.
Results
PWST, Tp-e, Tp-e/QTc and ICEB-c parameters, which are predictive of cardiac arrhythmia, did not show statistical differences in migraine patients (p-value 0.301, 0.967, 0.982 and 0.814 respectively).
Conclusion
Migraine, a disorder characterized by both neurological and vascular degeneration, does not possess a specific risk factor for cardiac arrhythmia. There is no significant difference in electrophysiological characteristics that can be used to predict cardiac arrhythmia in patients who have been followed up for a long period.
Keywords: Migraine, cardiac arrhythmia, autonomic nervous system, headache, paroxysmal atrial fibrillation, ventricular repolarization
References
Andreou AP, Edvinsson L. Mechanisms of migraine as a chronic evolutive condition. J Headache Pain. 2019;20()1:117.
Hoffmann J, Baca SM, Akerman S. Neurovascular mechanisms of migraine and cluster headache. J Cereb Blood Flow Metab. 2019;39(4):573-594.
Sacco S, Kurth T. Migraine and the risk for stroke and cardiovascular disease. Curr Cardiol Rep. 2014;16(9):524.
Bigal ME, Kurth T, Hu H, Santanello N, Lipton RB. Migraine and cardiovascular disease: possible mechanisms of interaction. Neurology. 2009;72(21):1864-1871.
Melek IM, Seyfeli E, Duru M, Duman T, Akgul F, Yalcin F. Autonomic dysfunction and cardiac repolarization abnormalities in patients with migraine attacks. Med Sci Monit. 2007;13(3):RA47-49.
Ashina M, Katsarava Z, Do TP, Buse DC, Pozo-Rosich P, Özge A, et al. Migraine: epidemiology and systems of care. Lancet. 2021;397(10283):1485-1495.
Pierangeli G, Giannini G, Favoni V, Sambati L, Cevoli S, Cortelli P. Migraine and cardiovascular diseases. Neurol Sci. 2012;33 Suppl 1:S47-50.
Bigal ME. Migraine and cardiovascular disease. Arq Neuropsiquiatr. 2011;69(1):122-129.
Scher AI, Stewart WF, Ricci JA, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain. 2003;106(1-2):81-89.
Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ. Cardiovascular risk factors and migraine: the GEM population-based study. Neurology. 2005;64(4):614-620.
Öz A, Cinar T, Kızılto Güler C, Efe SÇ, Emre U, Karabağ T, et al. Novel electrocardiography parameter for paroxysmal atrial fibrillation in acute ischaemic stroke patients: P wave peak time. Postgrad Med J. 2020;96(1140):584-588.
Scutelnic A, Mattle HP, Branca M, Jung S, Reichlin T, Fischer U, et al. Migraine and atrial fibrillation: a systematic review. Eur J Neurol. 2022;29(3):910-920.
Zhao D, Liang B, Peng J, Tang L, Su R, Luo L, et al. Tp-e and (Tp-e)/QT ratio as a non-invasive risk factors for malignant ventricular arrhythmia in patients with idiopathic ventricular premature complexes. J Clin Lab Anal. 2021;35(2):e23636.
Öztürk M, Turan OE, Karaman K, Bilge N, Ceyhun G, Aksu U, et al. Evaluation of ventricular repolarization parameters during migraine attacks. J Electrocardiol. 2019;53:66-70.


